How much phenobarbital can a human take?

How much phenobarbital can a human take?

MAXIMUM DOSAGE 200 mg/day PO is a general estimation for outpatient chronic use. Specific maximum dosage information not available; individualize dosage based on monitoring of serum phenobarbital concentrations and clinical parameters. 200 mg/day PO is a general estimation for outpatient chronic use.

How do you give phenobarbital IV?

Loading Dose: 10 – 15 mg/kg IV (reduce to 5-10 mg/kg IV for patients with hypotension). Administer slowly over 1 hour. Infusion: Start at 0.5 – 1 mg/kg/hour and titrate slowly to a maximum dose of 0.5 – 10 mg/kg/hour as required to maintain a desired interburst interval (period of suppression on a continuous EEG.

How do you administer phenobarbital?

Phenobarbital sodium may be administered intramuscularly or intravenously as an anticonvulsant for emergency use. When administered intravenously, it may require 15 or more minutes before reaching peak concentrations in the brain.

How much phenobarbital does it take to overdose?

Phenobarbital Overdose A lethal dose of phenobarbital is 6-10 grams, which a person may have in their medicine cabinet if they have been prescribed this drug. As a daytime sedative, a doctor may prescribe anywhere from 30 mg to 120 mg, and as an insomnia treatment, an individual could take as much as 320 mg.

Can you overdose on phenobarbital?

An overdose of phenobarbital can be fatal. Overdose symptoms may include slow or shallow breathing, weak pulse, cold or clammy skin, little or no urination, pinpoint pupils, feeling cold, or fainting. Drinking alcohol with this medicine can cause side effects. This medication may impair your thinking or reactions.

How long does it take for phenobarbital to kick in?

Tablets or elixirs begin to act in about 60 minutes,2 and their duration lasts for 10 to 12 hours,3 depending on the dosage and individual metabolism. The plasma half-life of phenobarbital in adults is an average of about 79 hours and 110 hours in children.

What type of seizure is phenobarbital used for?

Phenobarbital is approved in the United States by the Food and Drug Administration (FDA) for add-on therapy for partial and tonic-clonic seizures. It has been used alone for more than 80 years, however, to treat partial and tonic-clonic seizures. It is also used for treatment of status epilepticus.

What is phenobarbital IV used for?

Phenobarbital is a prescription medicine used to treat and prevent the symptoms of seizures, sedation, hypnotics, Insomina and Status Epilepticus. Phenobarbital may be used alone or with other medications. Phenobarbital belongs to a class of drugs called Anticonvulsants, Barbiturates.

What is a toxic level of phenobarbital?

The therapeutic reference range of phenobarbital is 10-30 mcg/mL. The toxic reference range of phenobarbital is >40 mcg/mL.

What happens if you have too much phenobarbital?

What does phenobarbital do to the body?

Phenobarbital slows the activity of your brain and nervous system. Phenobarbital is used to treat or prevent seizures. Phenobarbital is also used short-term as a sedative to help you relax.

What are the long term side effects of phenobarbital?

Phenobarbital and phenytoin have good antiepileptic effect, but clinically significant untoward effects occur during their long-term use. Phenobarbital may cause hyperactivity, behavioral problems, sedation, and even dementia; these effects are dose related to some extent.

How many mg of phenobarbital can you take in one day?

4 to 6 mg/kg/day for 7 to 10 days or 5 to 15 mg/kg/day IM or IV. Status epilepticus: Parenteral: -Initial dose: 15 to 20 mg/kg IV over 10 to 15 minutes. Comments: -Loading doses of 15 to 20 mg/kg are predicted to produce blood levels of approximately 20 mcg/mL after administration.

What kind of injection is Phenobarbital sodium injection?

Phenobarbital Sodium Injection, USP is a sterile solution for intramuscular or slow intravenous administration as a long-acting barbiturate.

How long does it take for phenobarbital to take effect?

At the clinic or hospital, it can also be given as an injection. This medication can take a few weeks before full effects are noted, but gradual improvements are usually noticeable after several doses. What if I miss giving my pet the medication?

Is the Phenobarbital sodium injection safe for babies?

Phenobarbital Sodium Injection contains the preservative benzyl alcohol and is not recommended for use in neonates. There have been reports of fatal ‘gasping syndrome’ in neonates (children less than one month of age) following the administration of intravenous solutions containing the preservative benzyl alcohol.