What is an example of a bisphosphonate?

What is an example of a bisphosphonate?

Bisphosponates such as risedronate (Actonel), alendronate (Fosamax), ibandronate (Boniva), zoledronic acid (Reclast), and pamidronate (Aredia) are used to treat and prevent osteoporosis—or, bone thinning—which occurs when the bones lose calcium and other minerals that help keep them strong and compact.

Which medication is a bisphosphonate?

List of Bisphosphonates:

Drug Name Avg. Rating Reviews
Fosamax (Pro) Generic name: alendronate 3.1 54 reviews
Zometa (Pro) Generic name: zoledronic acid 4.8 37 reviews
Actonel (Pro) Generic name: risedronate 3.3 25 reviews
Aclasta Generic name: zoledronic acid 4.1 19 reviews

What does a bisphosphonate do?

Bisphosphonates, also known as diphosphonates, are a class of drugs that have been used commonly for more than two decades for the treatment and prevention of osteoporosis. Bisphosphonates slow bone resorption by reducing osteoclast function.

Is Evista a bisphosphonate?

Fosamax and Evista belong to different drug classes. Fosamax is a bisphosphonate and Evista is an estrogen agonist/antagonist.

Is bisphosphonates a chemotherapy?

Last, bisphosphonates in addition to chemotherapy are superior to chemotherapy alone in patients with stages II and III multiple myeloma and can reduce the skeletal morbidity rate by approximately one half.

How do bisphosphonates cause esophagitis?

When bisphosphonates bind, the hydrophobic barrier is destroyed, and gastric acid is able to reach the epithelium resulting in irritation. If bisphosphonates are taken properly, the rate of esophageal irritation is reduced.

Can bisphosphonates cause hair loss?

Alopecia is an adverse drug reaction which is labeled for all statins. Alopecia is disproportionally associated with alendronate and risedronate in both the Lareb database and in the database of the WHO. Lareb received 53 reports of alopecia associated with the treatment with bisphosphonates.

Is Evista the same as raloxifene?

Evista (chemical name: raloxifene) is a SERM approved by the U.S. Food and Drug Administration (FDA) to: reduce the risk of hormone-receptor-positive breast cancer in postmenopausal women who haven’t been diagnosed but are at higher-than-average risk for disease.

What are Bisphosphonates and how do they work?

Bisphosphonates work by slowing down the cells which break down bone (osteoclasts). Therefore they slow down bone loss, allowing the bone building cells ( osteoblasts ) to work more effectively. They can help to strengthen bone and help to prevent it getting any weaker.

When to stop bisphosphonate?

You may be able to discontinue therapy with bisphosphonates after 5 years of use if your fracture risk is low. Continue to follow up with your doctor for monitoring and repeat bone density scans about every 1-2 years; your doctor will decide how often the test should be repeated.

When to stop bisphosphonates?

Because the medication lasts in the bones for some time after you stop taking it, your doctor might recommend stopping bisphosphonates after three to five years — especially if your overall risk of fracture is low.

Is Fosamax an oral bisphosphonate?

Oral bisphosphonates such as Fosamax, Boniva , and Actonel are used by millions of osteoporosis patients in the U.S. and throughout the world to prevent further bone loss.

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