How much Depakote is toxic?

How much Depakote is toxic?

The therapeutic range is 350-690 µmol/L (50-100 mg/L). Control of symptoms may be improved with levels higher than 690 µmol/L (100 mg/L). Mild symptoms may occur when levels are in the therapeutic range. Serious intoxication is likely when levels exceed 450 mg/L.

Can Depakote cause increased liver enzymes?

The frequency of adverse effects (particularly elevated liver enzymes and thrombocytopenia) may be dose-related.

Is Depakote hard on the liver?

A: The following serious side effects are associated with Depakote: Serious liver damage that can cause death, especially in children younger than 2 years old. Risk of serious liver damage is more likely to occur within the first 6 months of treatment, and may continue despite discontinued use of the drug.

Can Depakote cause liver issues?

Can Depakote be lethal?

400 — 1000 mg/kg: severe toxicity, i.e. Coma. >1g/kg: potentially life threatening, i.e. profound coma, multi-organ toxicity including hypotension, metabolic (lactic) acidosis, cerebral oedema, biochemical abnormalities, bone marrow suppression.

Is Depakote toxic to the liver?

Depakote-induced hepatotoxicity has been well established as an adverse effect, and periodic monitoring of drug level is often required. Depakote-induced hepatotoxicity mostly occurs at supratherapeutic drug level.

Is Vyvanse bad for your liver?

Liver problems – Long-term liver damage has been known to occur in people who continually abuse Vyvanse. They may begin to notice fatigue, itching, confusion and a yellow tint to their skin and eyes. Kidney problems – The kidneys’ job is to create urine and remove waste from the blood.

What are the long term effects of Depakote?

Long-Term Side Effects of Depakote. Many of the serious side effects from taking Depakote are lifelong. For example, damage done to the unborn when their mothers take the drug can affect the child for his or her life. Also, liver damage cannot be cured or reversed.

Is there a cure for liver damage from Depakote?

Depakote and Liver Damage. It is a serious condition that can be fatal. There is no treatment, cure or reversal for liver damage. The primary treatment is to discontinue any medications processed through the liver and to avoid alcohol. Doctors may prescribe medications that help to reduce the symptoms of liver damage.

Can a 2 year old die from Depakote?

Serious liver damage that can cause death, especially in children younger than 2 years old. The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment. In some cases, liver damage may continue despite stopping the drug.

When does hepatotoxicity of Depakote usually occur?

Evidence suggests that hepatotoxicity most typically occurs within the patient’s first six months taking Depakote. It is recommended that blood testing is periodically performed to monitor the patient’s liver function.